No, 2,4-D is not an endocrine disruptor. The Environmental Protection Agency (EPA) has reviewed this in its 2005 decision, and reassessed during its most recent NRDC petition response. In both instances the EPA determined that 2,4-D was not an endocrine disruptor. “No convincing evidence of potential interaction with estrogen, androgen or thyroid pathways,”

This evaluation was last revisited and confirmed by the European Food Safety Authority  in 2023 and by the EPA in 2017.